Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3077-9. doi: 10.1016/s0960-894x(02)00648-0.

Abstract

Biaryl nitrile amines were prepared and found to have high affinity and selectivity for human and rat histamine H(3) receptors.

MeSH terms

  • Animals
  • Biphenyl Compounds / chemical synthesis*
  • Biphenyl Compounds / pharmacology*
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism
  • Guinea Pigs
  • Humans
  • In Vitro Techniques
  • Ligands
  • Nitriles / chemical synthesis*
  • Nitriles / pharmacology*
  • Rats
  • Receptors, Histamine H1 / drug effects
  • Receptors, Histamine H1 / metabolism
  • Receptors, Histamine H2 / drug effects
  • Receptors, Histamine H2 / metabolism
  • Receptors, Histamine H3 / drug effects*
  • Structure-Activity Relationship

Substances

  • Biphenyl Compounds
  • Ligands
  • Nitriles
  • Receptors, Histamine H1
  • Receptors, Histamine H2
  • Receptors, Histamine H3